Document Type
Thesis
College
College of Pharmacy and Health Sciences
Department
Pharmaceutical and Administrative Sciences
Degree
MS in Pharmaceutical Sciences
Date Completed
Spring 2024
First Committee Member
Mizuno, Cassia
Second Committee Member
Koomoa-Lange, Ingo
Abstract
Previous studies have found that Autism Spectrum Disorder (ASD) has been linked to Serotonin Receptor 7 (5-HT7) agonism. Activation of this receptor has been linked to reduction in repetitive and restrictive behaviors often associated with Autism Spectrum Disorder. Known 5-HT7 agonists have only partial agonism or are nonspecific to the 5-HT7 receptor, therefore, optimization of these structures is needed for potentially greater pharmacological effects. This article focuses on the design and synthesis of 10 novel compounds, and their pharmacological evaluation of novel compounds as potential 5-HT7 agonists. In total, ten novel compounds were synthesized. We are pleased to report that all compounds have the ability to inhibit 70% to 100% of the specific ligand to the 5-HT7 receptor. Further investigation of the specific Ki values is underway.
Recommended Citation
Robertson, Hallie, "Synthesis of Novel 5-HT7 Receptor Agonists and the Potential Pharmacological Effect on Autism Spectrum Disorder" (2024). Master’s Theses - College of Pharmacy and Health Sciences. 4.
https://digitalcommons.law.wne.edu/cophstheses/4
