Document Type
Thesis
College
College of Pharmacy and Health Sciences
Department
Pharmaceutical and Administrative Sciences
Degree
MS in Pharmaceutical Sciences
Date Completed
Spring 2024
First Committee Member
Jaiswal, Devina
Second Committee Member
Rust, Michael
Abstract
An advanced drug delivery system known as lipid nanoparticles, which manipulates particle flow on a nanoscale, is favored in the pharmaceutical industry for its personalized precision therapy capabilities. This drug delivery system can cross the blood brain barrier, due to its immense size reduction. Formulating a uniform size distribution of a lipid nanoparticle product is a major challenge associated with current nanoparticle synthesis methods. However, an emerging technique utilizing microfluidic technology and devices have shown promise in synthesizing nanoparticles. Existing microfluidic chip designs were adapted and improved to enhance the mixing capabilities to yield a lipid emulsion on the device. This thesis aimed to design a microfluidic chip for a uniform size distribution of a lipid nanoparticle emulsion and was achieved. The final microfluidic chip was fabricated featuring a flow focus “cutting” geometry to cut particles at a two-inlet flow rate system. The device particle generation and characterization were analyzed with particle size analysis via dynamic light scattering and consistently yielded precise nanoparticles with a size of 860 nm – 920 nm and a PDI < 0.5.
Recommended Citation
Pompi, Alyssa M., "Microfluidic Chip for Uniform Size Distribution of a Lipid Nanoparticle Emulsion" (2024). Master’s Theses - College of Pharmacy and Health Sciences. 3.
https://digitalcommons.law.wne.edu/cophstheses/3
