Document Type

Thesis

College

College of Engineering

Department

Mechanical Engineering

Degree

MSE in Mechanical Engineering

Date Completed

2015

First Committee Member

Lipkins, Bart

Second Committee Member

Kennedy, Daniel

Third Committee Member

Riofrio, Jose

Additional Committee Member(s)

Rust, Michael; Cheraghi, Hossein

Abstract

"Blood filtration is a commonly utilized technique for the separation and isolation of red blood cells (RBCs), white blood cells (WBCs), and platelets from blood. Current blood filtration technology includes using centrifuges and membrane filters to isolate these cells from the blood. Acoustophoresis, the process of using an acoustic pressure field to selectively deflect and collect particles, is a proven blood cell separation technique in micro-electromechanical systems, but has not been scaled up for larger flow rates to meet the clinical need required by some applications. In this work, a system was designed and evaluated as a potential blood filtration device that utilized acoustics and processed blood at the macro-scale, or flow rates on the order of liters per hour. A device was designed and evaluated for RBC, WBC, and platelet concentration performance. Several process improvement tests evaluating the effect of priming, frequency, power, and dilution were performed. Viability measurements were also performed on the cells to determine if the process had any detrimental effects on the cells."

Share

COinS