Document Type
Thesis
College
College of Engineering
Department
Mechanical Engineering
Degree
MSE in Mechanical Engineering
Date Completed
2015
First Committee Member
Lipkins, Bart
Second Committee Member
Kennedy, Daniel
Third Committee Member
Riofrio, Jose
Additional Committee Member(s)
Rust, Michael; Cheraghi, Hossein
Abstract
"Blood filtration is a commonly utilized technique for the separation and isolation of red blood cells (RBCs), white blood cells (WBCs), and platelets from blood. Current blood filtration technology includes using centrifuges and membrane filters to isolate these cells from the blood. Acoustophoresis, the process of using an acoustic pressure field to selectively deflect and collect particles, is a proven blood cell separation technique in micro-electromechanical systems, but has not been scaled up for larger flow rates to meet the clinical need required by some applications. In this work, a system was designed and evaluated as a potential blood filtration device that utilized acoustics and processed blood at the macro-scale, or flow rates on the order of liters per hour. A device was designed and evaluated for RBC, WBC, and platelet concentration performance. Several process improvement tests evaluating the effect of priming, frequency, power, and dilution were performed. Viability measurements were also performed on the cells to determine if the process had any detrimental effects on the cells."
Recommended Citation
Dutra, Brian P., "Feasibility study on the efficacy of an acoustophoretic blood filtration system" (2015). Master’s Theses - College of Engineering. 2.
https://digitalcommons.law.wne.edu/coetheses/2